PathHunter® U2OS CSF2RB/CSF2RA Dimerization Cell Line

Background Information:

The PathHunter® CSF2RB/CSF2RA Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. GM-CSF) induced dimerization of CSF2RB/CSF2RA receptors. This product uses EFC technology. The cell line included overexpresses CSF2RB target protein fused to PK alongside CSF2RA target protein fused to EA. Upon ligand-induced dimerization of CSF2RB/CSF2RA , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Cytokine Receptor

Family:

IL-3 Receptor

Protein Name:

CSF2RB

Protein Aliases:

Colony stimulating factor 2 receptor beta common subunit

Accession Number:

NM_000395.2

UniProt Number:

Q6NSJ8

Gene Name:

CSF2RB

Gene ID:

1439

Target Species:

Human

Cell Background:

U2OS