PathHunter® U2OS AMHR2/BMPR1A Dimerization Cell Line

Background Information:

The PathHunter® AMHR2/BMPR1A Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. MIS/AMH) induced dimerization of AMHR2/BMPR1A receptors. This product uses EFC technology. The cell line included overexpresses AMHR2 target protein fused to PK alongside BMPR1A target protein fused to EA. Upon ligand-induced dimerization of AMHR2/BMPR1A, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

RSTK

Sub Family:

Protein Ser/Thr

Protein Name:

ALK3

Protein Aliases:

BMPR-1A|Activin receptor-like kinase 3|ALK-3|Serine/threonine-protein kinase receptor R5|SKR5|CD antigen CD292

Accession Number:

NM_004329.3

UniProt Number:

P36894

Gene Name:

BMPR1A

Gene ID:

657

Gene Aliases:

ALK3|CD292|ACVRLK3

Target Species:

Human

Cell Background:

U2OS