PathHunter® U2OS ACVR1C/ACVR2B Dimerization Cell Line

Background Information:

The PathHunter® ACVR1C/ACVR2B Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. activin B) induced dimerization of ACVR1C/ACVR2B receptors. This product uses EFC technology. The cell line included overexpresses ACVR2B target protein fused to PK alongside ACVR1C target protein fused to EA. Upon ligand-induced dimerization of ACVR1C/ACVR2B , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

RSTK

Sub Family:

Protein Ser/Thr

Protein Name:

ALK7

Protein Aliases:

Activin receptor type IC|ACTR-IC|Activin receptor-like kinase 7|ALK-7

Accession Number:

NM_145259.2

UniProt Number:

Q8NER5

Gene Name:

ACVR1C

Gene ID:

130399

Gene Aliases:

ALK7

Target Species:

Human

Cell Background:

U2OS