PathHunter® U2OS ACVR1/ACVR2 Dimerization Cell Line

Background Information:

The PathHunter® ACVR1/ACVR2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. [ligand]) induced dimerization of ACVR1/ACVR2 receptors. This product uses EFC technology. The cell line included overexpresses ACVR1/ACVR2 target protein fused to PK alongside TGFBR2 target protein fused to EA. Upon ligand-induced dimerization of ACVR1/ACVR2 , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

RSTK

Sub Family:

Protein Ser/Thr

Protein Name:

ALK2

Protein Aliases:

Activin receptor type I|ACTR-I|Activin receptor-like kinase 2|ALK-2|Serine/threonine-protein kinase receptor R1|SKR1|TGF-B superfamily receptor type I|TSR-I

Accession Number:

NM_001616

UniProt Number:

Q04771

Gene Name:

ACVR1

Gene ID:

90

Gene Aliases:

SKR1|ALK2|ACVR1A

Target Species:

Human

Cell Background:

U2OS