PathHunter® Jurkat mPD-1 Signaling Cell Line

Background Information:

The PathHunter® Jurkat mPD-1 Signaling Cell Line is a stable, engineered cell line for use in studying drug candidates targeting signaling checkpoints. This cell line enables assessment of ligand-based activation of mPD-1 receptors via detection of SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged mPD-1 target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells. Please note this product expresses the mouse version of PD-1.

Target Class:

Checkpoint Receptor

Family:

IgSF

Sub Family:

Immune Inhibitory Receptor

Protein Name:

PD-1

Protein Aliases:

Protein PD-1|mPD-1|CD279

Accession Number:

NM_008798

UniProt Number:

Q02242

Gene Name:

Pdcd1

Gene ID:

18566

Gene Aliases:

PD-1|Pdc1|Ly101

Target Species:

Mouse

Cell Background:

Jurkat