PathHunter® Jurkat mCTLA4 Signaling Cell Line

Background Information:

The PathHunter® Jurkat mCTLA-4 Signaling Cell Line is a stable, engineered cell line for use in studying drug candidates targeting signaling checkpoints. This cell line enables assessment of ligand-based activation of mCTLA-4 receptors via detection of SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged mCTLA-4 target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells. Please note this product expresses the mouse version of CTLA-4.

Target Class:

Checkpoint Receptor

Family:

IgSF

Sub Family:

Immune Inhibitory Receptor

Protein Name:

CTLA4

Protein Aliases:

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4)|CD152

Accession Number:

NM_009843.4

UniProt Number:

P09793

Gene Name:

Ctla4

Gene ID:

12477

Gene Aliases:

Cd152|Ly-56|Ctla-4

Target Species:

Mouse

Cell Background:

Jurkat