Biological Information

Background Information:

The PathHunter® Signaling Reporter Cell Lines are stable clonal cell lines that monitor the activation of specific signaling pathways, utilizing the established PathHunter® Enzyme Fragment Complementation (EFC) technology. Each stable cell line is engineered to express a synthetic DNA reporter construct, comprising a pathway-specific transcription factor response element that drives expression of ePL-tagged reporter protein. The activated signaling pathway induces expression of the ePL-tagged reporter protein, which is measured by addition of the detection reagent containing EA, resulting in complementation of the two enzyme fragments, and production of an active enzyme that hydrolyzes the substrate to generate a chemiluminescent signal.

Target Class:

Cytokine Receptor

Family:

Interferon Receptor

Protein Name:

IFN-gamma R1

Protein Aliases:

IFN-gamma-R1|CDw119|Interferon gamma receptor alpha-chain|IFN-gamma-R-alpha|CD antigen CD119

Accession Number:

NM_000619

UniProt Number:

P15260

Gene Name:

IFNGR1

Gene ID:

3459

Target Species:

Human

Cell Background:

HEK293

Usage

Product Type:

Stable Cell Lines

Application:

Signaling Reporters

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Assay Information

Assay Type:

Cell Based

Assay Measures:

Signaling

Detection Method:

Chemiluminescence

Bioassay Data

Trademark Statement:

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Clinical Relevance

Therapeutic Area:

Inflammation/Allergy

Additional Information

Brand:

PathHunter®