PathHunter® HEK 293 AR Nuclear Translocation Cell Line

Background Information:

The PathHunter® AR Nuclear Translocation cell line is a stable, engineered cell line for use in studying drug candidates affecting NHR activation and nuclear translocation. This cell line enables assessment of ligand (e.g. testosterone, fluorotestosterone) based NHR activation via detection of resulting AR nuclear translocation. This product uses EFC technology. The included cell line overexpresses PL-tagged AR NHR and nuclear localized EA. Upon activation of AR, induced nuclear translocation leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

NHR

Family:

3-Ketosteroid

Sub Family:

Steroid

Protein Name:

AR

Protein Aliases:

testicular feminization|Kennedy disease

Accession Number:

NM_000044

UniProt Number:

P10275

Gene Name:

AR

Gene ID:

367

Gene Aliases:

AIS|NR3C4|SMAX1|HUMARA

Target Species:

Human

Cell Background:

HEK293