KILR® U2OS PD-L1 Cell Line

Background Information:

The KILR® U2OS PD-L1 cell line is a stable, engineered target cell line to measure direct cell death mediated by immuno-oncology treatments (e.g. checkpoint inhibitors, checkpoint agonists, bispecifics, CAR-T, and more) via Antibody Dependent Cell-mediated Cytotoxicity (ADCC), Complement Dependent Cytotoxicity (CDC), and Antibody Dependent Cell Phagocytosis (ADCP). This product uses EFC technology. The cell line overexpresses a PL- tagged housekeeping gene. Once the cells have been lysed by effector cells, PL is released to the media, where EA contained in the detection kit produces an EFC signal proportional to the level of PL released. This allows for calculation of percent lysis of the KILR® cell line.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Checkpoint Receptor

Family:

IgSF

Sub Family:

Immune Inhibitory Receptor Ligand

Protein Name:

PD-L1

Protein Aliases:

PDCD1 ligand 1|CD274 molecule|B7 homolog 1|B7-H1|CD antigen CD274

Accession Number:

NM_014143.3

UniProt Number:

Q9NZQ7

Gene Name:

CD274

Gene ID:

29126

Gene Aliases:

B7H1|PDCD1L1|PDCD1LG1|PDL1

Target Species:

Human

Cell Background:

U2OS