InCELL Hunter™ A549 PRMT3 Methyltransferase Cell Line

Background Information:

The InCELL Hunter™ A549 PRMT3 Methyltransferase Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with regulators of epigenetics pathways. This cell line enables assessment of compound-engagement-based stabilization of PRMT3 via detection of PRMT3 levels. This product uses EFC technology. The cell line included overexpresses PRMT3 target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Epigenetic

Family:

Protein Arginine N-Methyltransferase

Sub Family:

Writer

Protein Name:

PRMT3

Protein Aliases:

Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3

Accession Number:

NM_005788.3

UniProt Number:

O60678

Gene Name:

PRMT3

Gene ID:

10196

Gene Aliases:

HRMT1L3

Target Species:

Human

Cell Background:

A549