CHO-K1 GNRHR Gq Cell Line

Background Information:

The GNRHR Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. GNRH) based activation of GNRHR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GNRHR , a naturally Gq coupled GPCR. Upon activation of GNRHR , the resulting calcium activity can be fluorescently assayed using the Calcium NoWash PLUS Detection Kit.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Gonadotrophin-Releasing Hormone

Sub Family:

Class A

Coupling:

Gq

Protein Name:

GnRH

Protein Aliases:

GnRH-R

Accession Number:

NM_000406.2

UniProt Number:

P30968

Gene Name:

GNRHR

Gene ID:

2798

Gene Aliases:

LHRHR

Target Species:

Human

Cell Background:

CHO-K1