Biological Information

Background Information:

The cAMP Hunter™ GRM6 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. L-glutamate) based activation of GRM6 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type GRM6 , a naturally Gi/Go coupled GPCR. Upon activation of GRM6 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Glutamate (Metabotropic)

Sub Family:

Class C

Coupling:

Gi/Go

Protein Name:

mGlu6

Accession Number:

NM_000843

UniProt Number:

O15303

Gene Name:

GRM6

Gene ID:

2916

Gene Aliases:

GPRC1F|mGlu6|MGLUR6|CSNB1B

Target Species:

Human

Cell Background:

CHO-K1

Usage

Product Type:

Stable Cell Lines

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

cAMP Detection

Detection Method:

Chemiluminescence

Additional Information

Brand:

cAMP Hunter™