cAMP Hunter™ CHO-K1 GRM2 Gi Cell Line

Background Information:

The cAMP Hunter™ GRM2 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. L-glutamate) based activation of GRM2 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type GRM2 , a naturally Gi/Go coupled GPCR. Upon activation of GRM2 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Glutamate (Metabotropic)

Sub Family:

Class C

Coupling:

Gi/Go

Protein Name:

mGlu2

Accession Number:

NM_000839

UniProt Number:

Q14416

Gene Name:

GRM2

Gene ID:

2912

Gene Aliases:

GPRC1B|mGlu2|MGLUR2

Target Species:

Human

Cell Background:

CHO-K1