cAMP Hunter™ CHO-K1 FPRL1 Gi Cell Line

Background Information:

The cAMP Hunter™ FPRL1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of FPRL1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type FPRL1 , a naturally Gi/Go coupled GPCR. Upon activation of FPRL1 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Formylpeptide

Sub Family:

Class A

Coupling:

Gi/Go

Protein Name:

FPR2

Protein Aliases:

FMLP-R-I|Formyl peptide receptor-like 1|HM63|Lipoxin A4 receptor|LXA4 receptor|RFP

Accession Number:

AY225226

UniProt Number:

P25090

Gene Name:

FPR2

Gene ID:

2358

Gene Aliases:

LXA4R|HM63|FPRH2|FMLPX|FPR2A|FMLP-R-II|ALXR|FPR|FMLP

Target Species:

Human

Cell Background:

CHO-K1