Biological Information

Background Information:

UbcH4 is a ubiquitin-conjugating enzyme (E2) that plays a central role in the ubiquitin–proteasome system (UPS), which governs targeted protein degradation, signal transduction, and proteostasis. Functionally, UbcH4 receives activated ubiquitin from the E1 ubiquitin-activating enzyme (UBA1) and collaborates with a wide variety of E3 ubiquitin ligases to transfer ubiquitin to specific substrate proteins, forming mono- or polyubiquitin chains that determine substrate fate. Dysregulated UbcH4 activity has been observed in multiple cancers e.g., breast, ovarian, and hepatocellular carcinoma, often correlating with altered ubiquitination of proteins such as p53 and beta-catenin.

Target Class:

Ubiquitination-related

Family:

ubiquitin-conjugating enzyme

Sub Family:

Transferase

Protein Name:

UbcH4

Protein Aliases:

UBCH5B; UBE2D2

Accession Number:

NM_003339.2

UniProt Number:

P62837

Gene Name:

UBE2D2

Gene ID:

7322

Gene Aliases:

UBC4; PUBC1; UBCH4; UBC4/5; UBCH5B; E2(17)KB2

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Assay Measures:

ECL

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology