U2OS GRM1 Gq Cell Line

Background Information:

The GRM1 Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. L-glutamate) based activation of GRM1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GRM1 , a naturally Gq coupled GPCR. Upon activation of GRM1 , the resulting calcium activity can be fluorescently assayed using the Calcium NoWash PLUS Detection Kit.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Glutamate (Metabotropic)

Sub Family:

Class C

Coupling:

Gq

Protein Name:

mGlu1

Protein Aliases:

protein phosphatase 1, regulatory subunit 85

Accession Number:

NM_000838.2

UniProt Number:

Q13255

Gene Name:

GRM1

Gene ID:

2911

Gene Aliases:

GPRC1A|mGlu1|MGLUR1|PPP1R85

Target Species:

Human

Cell Background:

U2OS