Biological Information
Background Information:
This cell line enables assessment of ligand (e.g. TGF-β1) induced dimerization of TGFBR1/TGFBR2 receptors when co-expressed with endoglin (ENG). This product uses EFC technology. The cell line included overexpresses TGFBR1 target protein fused to PK alongside TGFBR2 target protein fused to EA and untagged ENG. Upon ligand-induced dimerization of TGFBR1/TGFBR2 (+ENG), detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.
Target Class:
Kinase
Family:
TKL
Sub Family:
Protein Ser/Thr
Protein Name:
TGFBR1
Protein Aliases:
activin A receptor type II-like kinase, 53kDa
Accession Number:
NM_004612
UniProt Number:
P36897
Gene Name:
TGFBR1
Gene ID:
7046
Gene Aliases:
ALK-5|ACVRLK4|ALK5|SKR4
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage disclaimer:
These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Cell Based
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Additional Information
Brand:
PathHunter®