PathHunter® U2OS RANK NF-κB Signaling Pathway Reporter Cell Line

Background Information:

The PathHunter® U2OS RANK NF-κB Signaling Pathway Reporter Cell Line is a stable, engineered cell line that overexpresses RANK. It can be used for studying drug candidates (small molecules or biologics) affecting the NF-kB pathway. This cell line enables assessment of NF-kB pathway stimulation based on changes in the expression of a NF-Kb response element-driven reporter protein. This product uses EFC technology. The included cell line expresses PL-tagged reporter protein under the control of a NF-Kb pathway-inducible transcriptional response element. Pathway activation induces expression of the PL-tagged protein, allowing detection of EFC signal upon addition of EA-containing detection reagent.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Signaling Pathway

Family:

Tumour Necrosis Factor (TNF)

Protein Name:

RANK

Protein Aliases:

ODFR|TNF receptor superfamily member 11a|CD antigen CD265

Accession Number:

NM_003839.3; NM_003998.4

UniProt Number:

Q9Y6Q6

Gene Name:

TNFRSF11A

Gene ID:

8792

Gene Aliases:

RANK

Target Species:

Human

Cell Background:

U2OS