PathHunter® U2OS mCCR1 β-Arrestin Cell Line

Background Information:

The PathHunter® mCCR1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. [ligand]) based activation of mCCR1 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged mCCR1 and EA-tagged β-Arrestin 2. Activation of mCCR1 stimulates the recruitment of β-Arrestin 2 and produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the mouse version of this protein.

Target Class:

GPCR

Family:

Chemokine

Sub Family:

Class A

Coupling:

Gi/Go

Protein Name:

CCR1

Protein Aliases:

CC-CKR-1|CCR-1|CCR1|HM145|LD78 receptor|Macrophage inflammatory protein 1-alpha receptor|MIP-1alpha-R|RANTES-R|CD antigen CD191

Accession Number:

NM_009912

UniProt Number:

P51675

Gene Name:

CCR1

Gene ID:

12768

Gene Aliases:

CKR-1|MIP1aR|CD191

Target Species:

Mouse

Cell Background:

U2OS