Biological Information
Background Information:
The PathHunter® IL20RA/IL10RB Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-26) induced dimerization of IL20RA/IL10RB receptors. This product uses EFC technology. The cell line included overexpresses IL20RA target protein fused to PK alongside IL10RB target protein fused to EA. Upon ligand-induced dimerization of IL20RA/IL10RB , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.
Target Class:
Cytokine Receptor
Family:
IL-10 Receptor
Protein Name:
IL20RA
Protein Aliases:
IL-20R-alpha|IL-20RA|Cytokine receptor class-II member 8|Cytokine receptor family 2 member 8|CRF2-8|IL-20R1|ZcytoR7
Accession Number:
NM_014432.3
UniProt Number:
Q9UHF4
Gene Name:
IL20RA
Gene ID:
53832
Gene Aliases:
UNQ681/PRO1315
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage disclaimer:
These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Cell Based
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
PathHunter®