PathHunter® U2OS BMPR1B/ACVR2A Dimerization Cell Line

Background Information:

The PathHunter® BMPR1B/ACVR2A Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. BMP-6) induced dimerization of BMPR1B/ACVR2A receptors. This product uses EFC technology. The cell line included overexpresses BMPR1B target protein fused to PK alongside ACVR2A target protein fused to EA. Upon ligand-induced dimerization of BMPR1B/ACVR2A , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

TKL

Sub Family:

Protein Ser/Thr

Protein Name:

ALK6

Protein Aliases:

BMPR-1B|CD antigen CDw293

Accession Number:

NM_001256793.1 

UniProt Number:

O00238

Gene Name:

BMPR1B

Gene ID:

658

Gene Aliases:

ALK6|CDw293

Target Species:

Human

Cell Background:

U2OS