PathHunter® U2OS β-Catenin Nuclear Translocation Cell Line

Background Information:

The PathHunter® U2OS β-Catenin Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting NHR activation and nuclear translocation. This cell line enables assessment of ligand (e.g. Wnt ligands) based NHR activation via detection of resulting β-Catenin nuclear translocation. This product uses EFC technology. The included cell line overexpresses ED-tagged β-Catenin and nuclear localized EA. Upon activation of β-Catenin, induced nuclear translocation leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Nuclear Protein

Protein Name:

beta-Catenin

Accession Number:

NM_001904

UniProt Number:

P35222

Gene Name:

CTNNB1

Gene ID:

1499

Gene Aliases:

CTNNB|OK/SW-cl.35|PRO2286

Target Species:

Human

Cell Background:

U2OS