PathHunter® CHO-K1 LXRα Nuclear Translocation Cell Line

Background Information:

The PathHunter® LXRα Nuclear Translocation cell line is a stable, engineered cell line for use in studying drug candidates affecting NHR activation and nuclear translocation. This cell line enables assessment of ligand (e.g. oxysterols) based NHR activation via detection of resulting LXRα nuclear translocation. This product uses EFC technology. The included cell line overexpresses PL-tagged LXRα NHR and nuclear localized EA. Upon activation of LXRα, induced nuclear translocation leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

NHR

Family:

Liver X Receptor-Like

Sub Family:

Non-Steroid

Protein Name:

LXRalpha

Protein Aliases:

liver X receptor-alpha

Accession Number:

NM_005693

UniProt Number:

Q13133

Gene Name:

NR1H3

Gene ID:

10062

Gene Aliases:

LXR-a|RLD-1

Target Species:

Human

Cell Background:

CHO-K1