Biological Information
Background Information:
The InCELL Hunter™ HEK 293 TAF1L(2) Bromodomain Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with regulators of epigenetics pathways. This cell line enables assessment of compound-engagement-based stabilization of TAF1L(2) via detection of TAF1L(2) levels. This product uses EFC technology. The cell line included overexpresses TAF1L(2) target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.
Target Class:
Epigenetic
Family:
Bromodomain-Containing
Sub Family:
Reader
Protein Name:
TAF1L
Protein Aliases:
II210|TBP-associated factor 1-like|TBP-associated factor 210 kDa|Transcription initiation factor TFIID 210 kDa subunit
Accession Number:
NM_153809.2
UniProt Number:
Q8IZX4
Gene Name:
TAF1L
Gene ID:
138474
Target Species:
Human
Cell Background:
HEK293
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage disclaimer:
These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Cell Based Binding
Assay Measures:
Target Engagement
Detection Method:
Chemiluminescence
Additional Information
Brand:
InCELL Hunter™