InCELL Hunter™ HEK 293 BRD2(1) Bromodomain Cell Line

Background Information:

The InCELL Hunter™ HEK 293 BRD2(1) Bromodomain Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with regulators of epigenetics pathways. This cell line enables assessment of compound-engagement-based stabilization of BRD2(1) via detection of BRD2(1) levels. This product uses EFC technology. The cell line included overexpresses BRD2(1) target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Epigenetic

Family:

Bromodomain-Containing

Sub Family:

Reader

Protein Name:

BRD2

Protein Aliases:

Really interesting new gene 3 protein

Accession Number:

NM_005104.3

UniProt Number:

P25440

Gene Name:

BRD2

Gene ID:

6046

Gene Aliases:

KIAA9001|RING3|D6S113E|NAT|FSRG1

Target Species:

Human

Cell Background:

HEK293