cAMP Hunter™ CHO-K1 MCHR1 Gi Cell Line

Background Information:

The cAMP Hunter™ MCHR1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. melanin concentrating hormone) based activation of MCHR1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type MCHR1 , a naturally Gi/Go coupled GPCR. Upon activation of MCHR1 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Melanin-Concentrating Hormone

Sub Family:

Class A

Coupling:

Gi/Go

Protein Name:

MCH1

Protein Aliases:

MCH-R1|MCHR-1|G-protein coupled receptor 24|MCH-1R|MCH1R|MCHR|SLC-1|Somatostatin receptor-like protein

Accession Number:

AY562945

UniProt Number:

Q99705

Gene Name:

MCHR1

Gene ID:

2847

Gene Aliases:

SLC1|MCH1R

Target Species:

Human

Cell Background:

CHO-K1