cAMP Hunter™ CHO-K1 GALR1 Gi Cell Line

Background Information:

The cAMP Hunter™ GALR1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. galanin) based activation of GALR1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type GALR1 , a naturally Gi/Go coupled GPCR. Upon activation of GALR1 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Galanin

Sub Family:

Class A

Coupling:

Gi/Go

Protein Name:

GAL1

Protein Aliases:

GALR-1

Accession Number:

AY541036

UniProt Number:

P47211

Gene Name:

GALR1

Gene ID:

2587

Target Species:

Human

Cell Background:

CHO-K1