cAMP Hunter™ CHO-K1 CNR2 Gi Cell Line

Background Information:

The cAMP Hunter™ CNR2 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CP 55,940) based activation of CNR2 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CNR2 , a naturally Gi/Go coupled GPCR. Upon activation of CNR2 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Cannabinoid

Sub Family:

Class A

Coupling:

Gi/Go

Protein Name:

CB2

Protein Aliases:

CB2|hCB2|CX5

Accession Number:

AY242132

UniProt Number:

P34972

Gene Name:

CNR2

Gene ID:

1269

Gene Aliases:

CB2

Target Species:

Human

Cell Background:

CHO-K1