cAMP Hunter™ CHO-K1 ADRA2C Gi Cell Line

Background Information:

The cAMP Hunter™ ADRA2C Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. epinephrine and norepinephrine) based activation of ADRA2C GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type ADRA2C , a naturally Gi/Go coupled GPCR. Upon activation of ADRA2C , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Adrenoceptor

Sub Family:

Class A

Coupling:

Gi/Go

Protein Name:

alpha2C

Protein Aliases:

Alpha-2C adrenoreceptor|Alpha-2C adrenoceptor|Alpha-2CAR

Accession Number:

NM_000683

UniProt Number:

P18825

Gene Name:

ADRA2C

Gene ID:

152

Gene Aliases:

ADRA2L2|ADRA2RL2

Target Species:

Human

Cell Background:

CHO-K1