Biological Information

Background Information:

c-Kit (V654A) is an acquired resistance mutation which has been found in patients with gastrointestinal stromal tumors (GISTs) undergoing treatment with Imatinib. The V654A mutation is strongly correlated with Imatinib resistance and rapid progression of GISTs. (Chen LL et al., Cancer Research, (2004); 64:5913-5919).

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

Kit

Protein Aliases:

Piebald trait protein|PBT|Proto-oncogene c-Kit|Tyrosine-protein kinase Kit|p145 c-kit|v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog|CD antigen CD117

Accession Number:

NM_000222.2; NM_001093772.1

UniProt Number:

P10721

Gene Name:

KIT

Gene ID:

3815

Gene Aliases:

CD117|SCFR|C-Kit

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology