U2OS CASR Gq Cell Line

Background Information:

The CASR Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. extracellular calcium) based activation of CASR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CASR , a naturally Gq coupled GPCR. Upon activation of CASR , the resulting calcium activity can be fluorescently assayed using the Calcium NoWash PLUS Detection Kit.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Calcium-Sensing

Sub Family:

Class C

Coupling:

Gi/Go & Gq

Protein Name:

CaS

Protein Aliases:

severe neonatal hyperparathyroidism

Accession Number:

NM_000388

UniProt Number:

P41180

Gene Name:

CASR

Gene ID:

846

Gene Aliases:

FHH|NSHPT|GPRC2A

Target Species:

Human

Cell Background:

U2OS