Biological Information

Background Information:

TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. It plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation. GenBank NM_003215. The recombinant protein contains the amino acid substitution F514V with reference to NM_003215. F514V is reported in GenBank CB985022.

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

TEC

Accession Number:

NM_003215.1

UniProt Number:

P42680

Gene Name:

TEC

Gene ID:

7006

Gene Aliases:

PSCTK4

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology