TTBK2, active

Background Information:

TTBK2 (Tau tubulin kinase 2) is a serine/threonine protein kinase that is involved in a variety of cellular processes, including regulation of the cytoskeleton, intracellular transport, and neuronal development and function. TTBK2 has been shown to be involved in the regulation of microtubule dynamics and stability, and alterations in TTBK2 expression and activity have been linked to neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Research has suggested that TTBK2 may also play a role in cancer. TTBK2 has been shown to be overexpressed in several types of cancer, including breast cancer and glioblastoma, and high levels of TTBK2 expression have been associated with poor prognosis. Additionally, TTBK2 has been suggested as a potential therapeutic target in cancer, and efforts to develop small-molecule inhibitors of the kinase are underway.

Target Class:

Kinase

Family:

CK1

Sub Family:

Protein Ser/Thr

Protein Name:

TTBK2

Accession Number:

BC071556.1

UniProt Number:

Q6IQ55

Gene Name:

TTBK2

Gene ID:

146057

Gene Aliases:

KIAA0847

Target Species:

Human