Rsk2/MAPKAP Kinase 1b, active

Background Information:

Rsk2, also known as Ribosomal Protein S6 Kinase A3, is a member of the RSK family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) Signaling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). The protein sequence is identical to that described in GenBank NM_004586 for human RSK2, over residues 2–end. The cDNA however is more closely related to the mouse sequence described in GenBank AY083469.

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

RSK2

Protein Aliases:

90 kDa ribosomal protein S6 kinase 3|p90-RSK 3|p90RSK3|Insulin-stimulated protein kinase 1|ISPK-1|MAP kinase-activated protein kinase 1b|MAPK-activated protein kinase 1b|MAPKAP kinase 1b|MAPKAPK-1b|Ribosomal S6 kinase 2|RSK-2|pp90RSK2

Accession Number:

NM_004586.2

UniProt Number:

P51812

Gene Name:

RPS6KA3

Gene ID:

6197

Gene Aliases:

RSK|RSK2|HU-3|ISPK1|MAPKAPK1B

Target Species:

Human