Rse, active

Background Information:

Rse (TYRO3 protein tyrosine kinase), also known as Brt, BYK, Dtk, Etk3, Sky, Tif, or even sea-related receptor tyrosine kinase, is a receptor tyrosine kinase with homology to Axl. Rse is widely expressed in the adult and present in variable amounts in neural, lymphoid, vascular, and reproductive tissues. It plays a role in PI-3 kinase signaling and clearance of apoptotic cells. Gas6 acts directly on mature osteoclasts through activation of Tyro 3 and p42/p44 MAPK, possibly contributing to the bone loss by estrogen deficiency. GenBank D17517

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

TYRO3 (RSE)

Protein Aliases:

Tyrosine-protein kinase BYK|Tyrosine-protein kinase DTK|Tyrosine-protein kinase RSE|Tyrosine-protein kinase SKY|Tyrosine-protein kinase TIF

Accession Number:

NM_006293.2

UniProt Number:

Q06418

Gene Name:

TYRO3

Gene ID:

7301

Gene Aliases:

Dtk|Brt|Tif|Sky|Etk-2|Rek

Target Species:

Human