Ready-to-Assay CXCR6 Chemokine Receptor Frozen Cells

Background Information:

The Ready-to-Assay CXCR6 Chemokine Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. CXCL16) based activation of CXCR6 GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress CXCR6 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CXCR6 , the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format.

Target Class:

GPCR

Family:

Chemokine

Sub Family:

Class A

Protein Name:

CXCR6

Protein Aliases:

CXCR-6|CDw186|G-protein coupled receptor STRL33|G-protein coupled receptor bonzo|CD antigen CD186

Accession Number:

NM_006564

UniProt Number:

O00574

Gene Name:

CXCR6

Gene ID:

10663

Gene Aliases:

TYMSTR|STRL33|BONZO|CD186

Target Species:

Human

Cell Background:

Chem-5