Biological Information

Background Information:

Rho-associated, coiled-coil containing protein kinase (ROCK), including the ROCK1 and ROCK2 isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. PKA and the two ROCKs have been reported to have opposite effects on neurite formation. More studies are needed to provide significant insights into the role of ROCK in several pathological processes. ROCK inhibitors have been shown the benefit for treatment of various cancers, inflammation, coronary artery spasms and hypertension.

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

ROCK2

Protein Aliases:

Rho kinase 2|Rho-associated, coiled-coil-containing protein kinase 2|Rho-associated, coiled-coil-containing protein kinase II|ROCK-II|p164 ROCK-2

Accession Number:

NM_005406.2

UniProt Number:

Q62868

Gene Name:

Rock2

Gene ID:

25537

Target Species:

Rat

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology