PKD2, active

Background Information:

Two serine/threonine protein kinase D isoforms (PKD1 and PKD2), belonging to the polycystin family, are involved in protein-protein and protein-carbohydrate adhesion. The two isoforms are known to interact, and also thought to be ion channel regulators. PKD2 (PKD4, APKD2) bears closest homology with PKCmicro; and PKCnu;. Stimuli that activate PKD2 include phorbol esters, gastrin, and classical and novel PKC family members. Defects in PKD (inhibition of function) is responsible for human autosomal dominant polycystic kidney disease (ADPKD) that causes progressive renal failure and may also lead to liver cysts. GenBank NM_016457

Target Class:

Kinase

Family:

CAMK

Sub Family:

Protein Ser/Thr

Protein Name:

PKD2

Protein Aliases:

nPKC-D2

Accession Number:

NM_001079880.1; NM_001079881.1; NM_001079882.1; NM_016457.4

UniProt Number:

Q9BZL6

Gene Name:

PRKD2

Gene ID:

25865

Gene Aliases:

PKD2|HSPC187|DKFZP586E0820

Target Species:

Human