PKC zeta, active

Background Information:

KPCZ (Protein kinase C, zeta type, nPKC-zeta, EC 2.7.1.37) is one of the major protein kinase C (PKC) isoforms of a family of serine/threonine protein kinases. Breakdown of phosphatidylinositol leads to formation of diacylglycerol and inositol triphosphate, the former acting synergistically with Ca2+ to activate PKC, resulting in translocation of the enzyme from cytosol to the membrane. Phosphorylation of proteins by PKC has been implicated as a pivotal regulatory element in signal transduction, cellular regulation, and with a high affinity to phorbol ester tumor promoters. GenBank BC014270

Target Class:

Kinase

Family:

PKC

Sub Family:

Protein Ser/Thr

Protein Name:

PKCzeta

Accession Number:

NM_001033581.1; NM_001033582.1; NM_002744.4

UniProt Number:

Q05513

Gene Name:

PRKCZ

Gene ID:

5590

Gene Aliases:

PKC2

Target Species:

Human