PDGFRalpha, active

Background Information:

Receptors that are tyrosine protein kinases include those receptors for platelet-derived growth factor (PDGF), insulin, epidermal growth factor (EGF) and certain lymphokines. Receptor tyrosine kinases are cell surface transmembrane proteins responsible for intracellular signal transduction. They are expressed in several cell types and, after activation by growth factor binding, trigger a series of intracellular pathways leading to a wide variety of responses; e.g. differentiation, proliferation, migration and invasion, angiogenesis, survival. Inhibition of PDGFA, Alpha platelet-derived growth factor receptor, PDGF-R-alpha, CD140a antigen) receptor kinase may be useful in the treatment of several tumors. GenBank M21574

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

PDGFRalpha

Protein Aliases:

PDGFR-alpha|Alpha platelet-derived growth factor receptor|Alpha-type platelet-derived growth factor receptor|CD140 antigen-like family member A|CD140a antigen|Platelet-derived growth factor alpha receptor|Platelet-derived growth factor receptor 2|PDGFR-2|CD antigen CD140a

Accession Number:

NM_006206.3

UniProt Number:

P16234

Gene Name:

PDGFRA

Gene ID:

5156

Gene Aliases:

CD140a|PDGFR2|GAS9|RHEPDGFRA

Target Species:

Human