PAK6, active

Background Information:

PAK6 is a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to co-translocate into the nucleus with AR in response to androgen. GenBank NM_020168

Target Class:

Kinase

Family:

STE

Sub Family:

Protein Ser/Thr

Protein Name:

PAK6

Protein Aliases:

PAK-5|p21-activated kinase 6|PAK-6

Accession Number:

NM_020168.3

UniProt Number:

Q9NQU5

Gene Name:

PAK6

Gene ID:

56924

Gene Aliases:

PAK5

Target Species:

Human