MST1, active

Background Information:

MST1 and MST2 contain a putative caspase cleavage site at the junction of the catalytic domain and the C-terminal region. MST is involved in a positive feedback loop in possible association with the SAPK and p38-MAPK pathways. MST1 has been shown activated in cellular apoptosis induced by a variety of stimuli. Inhibition of MST1 may inhibit Raf-1-mediated cell proliferation and result in apoptosis. GenBank NM_006282

Target Class:

Kinase

Family:

STE

Sub Family:

Protein Ser/Thr

Protein Name:

MST1

Protein Aliases:

mammalian sterile 20-like 1|yeast Ste20-like|kinase responsive to stress 2

Accession Number:

NM_006282.2

UniProt Number:

Q13043

Gene Name:

STK4

Gene ID:

6789

Gene Aliases:

MST1|KRS2|YSK3

Target Species:

Human