Biological Information

Background Information:

Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidermal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-Jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). GenBank AF074393

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

MSK1

Protein Aliases:

90 kDa ribosomal protein S6 kinase 5|Nuclear mitogen- and stress-activated protein kinase 1|RSK-like protein kinase|RSKL

Accession Number:

NM_004755.2; NM_182398.1

UniProt Number:

O75582

Gene Name:

RPS6KA5

Gene ID:

9252

Gene Aliases:

MSK1|RLPK

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -20°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology