Biological Information
Background Information:
MLK2 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phosphorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. GenBank NM_002446.2
Target Class:
Kinase
Family:
TKL
Sub Family:
Protein Ser/Thr
Protein Name:
MLK2
Protein Aliases:
MKN28 kinase|mixed lineage kinase 2|MKN28 derived nonreceptor_type serine/threonine kinase
Accession Number:
NM_002446.2
UniProt Number:
Q02779
Gene Name:
MAP3K10
Gene ID:
4294
Gene Aliases:
MST|MEKK10|MLK2
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
Usage disclaimer:
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Assay Information
Assay Type:
Enzymatic
Bioassay Data
Trademark Statement:
For Research Use Only
Clinical Relevance
Therapeutic Area:
CNS/Addiction/Pain