Biological Information
Background Information:
Mitogen-activated protein kinase (MAPK)-activated protein kinase 3 (MAPKAPK3) mediates multiple p38 MAPK-dependent inflammatory responses. This kinase can be activated in response to cellular stress and pro-inflammatory cytokines through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. p38 MAP kinase, activated through MKK3, is required for the production of inflammatory cytokines by both antigen-presenting cells and CD4+ T cells. GenBank NM_004635
Target Class:
Kinase
Family:
CAMK
Sub Family:
Protein Ser/Thr
Protein Name:
MAPKAPK3
Accession Number:
NM_004635.3
UniProt Number:
Q16644
Gene Name:
MAPKAPK3
Gene ID:
7867
Gene Aliases:
3pK|MAPKAP3|3PK
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
Usage disclaimer:
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Assay Information
Assay Type:
Enzymatic
Bioassay Data
Trademark Statement:
For Research Use Only
Clinical Relevance
Therapeutic Area:
Oncology/Immuno-Oncology