Biological Information

Background Information:

Mitogen-activated protein kinase (MAPK)-activated protein kinase 3 (MAPKAPK3) mediates multiple p38 MAPK-dependent inflammatory responses. This kinase can be activated in response to cellular stress and pro-inflammatory cytokines through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. p38 MAP kinase, activated through MKK3, is required for the production of inflammatory cytokines by both antigen-presenting cells and CD4+ T cells. GenBank NM_004635

Target Class:

Kinase

Family:

CAMK

Sub Family:

Protein Ser/Thr

Protein Name:

MAPKAPK3

Accession Number:

NM_004635.3

UniProt Number:

Q16644

Gene Name:

MAPKAPK3

Gene ID:

7867

Gene Aliases:

3pK|MAPKAP3|3PK

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology