LOK, active

Background Information:

LOK, also known as STK10 (Serine/Threonine Kinase 10), a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like Kinase kinases. LOK can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. LOK can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein Kinase kinase 1 pathway. GenBank NM_005990

Target Class:

Kinase

Family:

STE

Sub Family:

Protein Ser/Thr

Protein Name:

LOK

Protein Aliases:

lymphocyte-oriented kinase

Accession Number:

NM_005990.3

UniProt Number:

O94804

Gene Name:

STK10

Gene ID:

6793

Gene Aliases:

LOK|PRO2729

Target Species:

Human