JMJD2D

Background Information:

JMJD2D (Jumonji domain-containing protein 2D), also known as KDM4D, is a histone demethylase that belongs to the JmjC domain-containing protein family. It specifically targets di- and tri-methylated lysine residues on histones H3 and H4, and catalyzes their removal, leading to changes in chromatin structure and gene expression. JMJD2D is expressed in a variety of tissues, including the brain, heart, and liver, and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis.
JMJD2D has been shown to play a role in the development of several types of cancer, including breast, ovarian, and prostate cancers. It has also been implicated in the regulation of cellular metabolism, including the response to hypoxia and glucose metabolism. Therefore, JMJD2D has emerged as a potential target for the development of novel therapeutics for cancer and metabolic diseases.

Target Class:

Epigenetic

Family:

Histone Demethylase

Sub Family:

Eraser

Protein Name:

JMJD2D

Accession Number:

NM_018039.3

UniProt Number:

Q6B0I6

Gene Name:

KDM4D

Gene ID:

55693

Gene Aliases:

FLJ10251

Target Species:

Human