JAK3, active

Background Information:

Janus kinase 3 (JAK3) is a non-receptor tyrosine kinase belonging to the Janus family. It is activated by a variety of cytokine and growth factor receptors, resulting in signaling cascades that facilitate the activation of various downstream target genes. JAK3 mediates gene transcription through its well-characterized downstream signaling molecules, the signal transducers and activators of transcription proteins (STAT). Inhibition of JAK3 may impair erythropoietin (EPO)-induced erythropoiesis and protection from Bain damage following hypoxia. Inhibition may also adversely effect diabetes. GenBank AF513860

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

JAK3

Protein Aliases:

tyrosine-protein kinase JAK3|leukocyte Janus kinase

Accession Number:

NM_000215.2

UniProt Number:

P52333

Gene Name:

JAK3

Gene ID:

3718

Gene Aliases:

L-JAK|JAKL|LJAK|JAK3_HUMAN|JAK-3

Target Species:

Human