IRE1, active

Background Information:

IRE1 (Inositol-requiring enzyme 1) is a transmembrane protein kinase that is involved in the endoplasmic reticulum (ER) stress response pathway. It is a key regulator of the unfolded protein response (UPR), which is activated in response to ER stress to maintain ER homeostasis and promote cell survival. Research has suggested that IRE1 plays a role in several diseases, including cancer, diabetes, and neurodegenerative diseases. In cancer, activation of IRE1 has been shown to promote cell survival and tumor growth, and inhibition of IRE1 has been suggested as a potential cancer therapy. In diabetes, activation of IRE1 has been implicated in the development of insulin resistance and beta cell dysfunction. Additionally, IRE1 has been implicated in the regulation of neuronal survival and degeneration, making it a potential target for the treatment of neurodegenerative diseases.

Target Class:

Kinase

Family:

Other Protein Kinase

Sub Family:

Protein Ser/Thr

Protein Name:

IRE1

Protein Aliases:

inositol-requiring enzyme 1|Serine/threonine-protein kinase/endoribonuclease IRE1

Accession Number:

NM_001433

UniProt Number:

O75460

Gene Name:

ERN1

Gene ID:

2081

Gene Aliases:

IRE1|IRE1P

Target Species:

Human