Biological Information

Background Information:

IKKe is a non-canonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.

Target Class:

Kinase

Family:

Other Protein Kinase

Sub Family:

Protein Ser/Thr

Protein Name:

IKKepsilon

Protein Aliases:

IKK-E|IKK-epsilon|IkBKE|Inducible I kappa-B kinase|IKK-i

Accession Number:

NM_001193321.1

UniProt Number:

Q14164

Gene Name:

IKBKE

Gene ID:

9641

Gene Aliases:

IKKE|IKK-i|KIAA0151

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology